Prof. Dr. Thorsten Heinzel

Funktionen

• Professor für Biochemie
• Institutsdirektor

Forschungsgebiete

• Mechanismen der Transkriptionsregulation
• Therapeutische Einsatzmöglichkeiten von Histon-deacetylase-Inhibitoren
• Regulation zellulärer Signalwege durch Proteinacetylierung

Publikationen (die 10 wichtigsten)

1. Wieczorek, K. H. Gührs, T. Heinzel, "Assessment of HDACi-induced acetylation of nonhistone proteins by mass spectrometry", Methods Mol. Biol. 2017, 1510, 313-327.
2. Noack, N. Mahendrarajah, D. Hennig, L. Schmidt, F. Grebien, D. Hildebrand, M. Christmann, A. Sellmer, S. Mahboobi, B. Kaina, K. Kubatzky, T. Heinzel, O. H. Krämer, "Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells", Arch. Toxicol. 2016, DOI: 10.1007/s00204-016-1878-5.
3. Hennig, S. Müller, C. Wichmann, S. Drube, K. Pietschmann, L. Pelzl, M. Grez, G. Bug, T. Heinzel, O. H. Krämer, "Antagonism between granulocytic maturation and deacetylase inhibitor-induced apoptosis in acute promyelocytic leukaemia cells", Br. J. Cancer 2015, 112, 329-37.
4. Hennig, S. Schubert, H. Dargatz, E. Kostenis, A. Fahr, U. S. Schubert, T. Heinzel, D. Imhof,  "Novel insights into appropriate encapsulation methods for bioactive compounds into polymers: A study with peptides and HDAC inhibitors", Macromol. Biosci. 2014, 14, 69-80.
5. Licht, K. Noack, B. Schlott, M. Förster, Y. Schlenker, A. Licht, O. H. Krämer, T. Heinzel "Caspase-3 and Caspase-6 cleave STAT1 in leukemic cells", Oncotarget 2014, 5, 2305-17.
6. Buchwald, K. Pietschmann, P. Brand, A. Günther, N. P. Mahajan, T. Heinzel, O. H. Krämer "SIAH ubiquitin ligases target the nonreceptor tyrosine kinase ACK1 for ubiquitinylation and proteasomal degradation", Oncogene 2013, 32, 4913-20.
7. Brandl, T. Wagner, K. M. Uhlig, S. K. Knauer, R. H. Stauber, F. Melchior, G. Schneider, T. Heinzel, O. H. Kramer, "Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress", J. Mol. Cell Biol. 2012, 4, 284-293.
8. Buchwald, K. Pietschmann, J. P. Müller, F. D. Böhmer, T. Heinzel, O. H. Krämer "The ubiquitin-conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation", Leukemia 2010, 24, 1412-21.
9. H. Krämer, S. K. Knauer, G. Greiner, E. Jandt, S. Reichardt, K. H. Gührs, R. H. Stauber, F. D. Böhmer, T. Heinzel, "A phosphorylation-acetylation switch regulates STAT1 signaling", Genes Dev. 2009, 23, 223-235.
10. H. Krämer, S. K. Knauer, D. Zimmermann, R. H. Stauber, T. Heinzel, "Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis", Oncogene 2008, 27, 732-740.