Prof. Dr. Ute A. Hellmich

Functions

• Chair for Biostructural Interactions

Research

• neglected tropical deseases
• ion channels and membrane transporters
• functional and structural dynamics of structured and intrinsically disordered proteins
• membrane and lipid interactions, (covalent) drug interactions

Publications (selected 5 most recent)

1. A. Wagner, T. A. Le, M. Brennich, P. Klein, N. Bader, E. Diehl, D. Paszek, A. K. Weickhmann, N. Dirdjaja, R. L. Krauth-Siegel, B. Engels, T. Opatz, H. Schindelin, U. A. Hellmich, Angew. Chem. Int. Ed. 58, 3640 (2019).
2. Heiby, J.C., Goretzki, B., Johnson, C.M. et al. Methionine in a protein hydrophobic core drives tight interactions required for assembly of spider silk. Nat Commun 10, 4378 (2019).
3. J. C. B. Dietschreit, A. Wagner, T. A. Le, P. Klein, H. Schindelin, T. Opatz, B. Engels, U. A. Hellmich, C. Ochsenfeld, Angew. Chem. Int. Ed. 59, 12669 (2020).
4. McCray, B.A., Diehl, E., Sullivan, J.M. et al. Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension. Nat Commun 12, 1444 (2021).
5. Zhang, L., Simonsen, C., Zimova, L. et al. Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function. Nat Commun 13, 7483 (2022).