Prof. Dr. Oliver Werz

Functions

• Chair holder of Pharmaceutical/Medicinal Chemistry

Research

• Pathobiochemistry of inflammation and inflammation-induced cancer
• Molecular and biochemical pharmacology of anti-inflammatory and antineoplastic agents
• Gender-specific Medicine and Pharmacology (Gender Medicine / GenderTailored Therapy)
• Target-oriented drug discovery and bioanalytical processing of drugs
• Target identification and target validation
• Natural substances as active ingredients

Publications (selected 10 most recent)

1. Garscha, S. Voelker, S. Pace, J. Gerstmeier, B. Emini, S. Liening, A. Rossi, C. Weinigel, S. Rummler, U. S. Schubert, G. K. E. Scriba, E. Çelikoğlu, B. Çalışkan, E. Banoglu, L. Sautebin, O. Werz, "BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase / 5-lipoxygenase-activating protein (FLAP) complex assembly", Biochem. Pharmacol. 2016, 119, 17-26.
2. Gerstmeier, C. Weinigel, S. Rummler, O. Rådmark, O. Werz, U. Garscha, "Time-resolved in situ assembly of the leukotriene-synthetic 5-LO / FLAP complex in blood leukocytes", FASEB J. 2016, 30, 276-285.
3. Koeberle, C. Pergola, H. Shindou, S.C. Koeberle, T. Shimizu, S.A. Laufer, O. Werz, "Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with ER homeostasis", FASEB J. 2015, 29, 2439-2449.
4. Pergola, N. Gaboriaud-Kolar, N. Jestädt, S. König, M. Kritsanida, A. M. Schaible, H. Li, U. Garscha, C. Weinigel, D. Barz, K. F. Albring, O. Huber, A. L. Skaltsounis, O. Werz, "The indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase", J. Med. Chem. 2014, 57, 3715-3723.
5.   Reker, A. M. Perna, T. Rodrigues, P. Schneider, M. Reutlinger, B. Mönch, A. Koeberle, C. Lamers, M. Gabler, H. Steinmetz, R. Müller, M. Schubert-Zsilavecz, O. Werz, G. Schneider, "Revealing the macromolecular targets of complex natural products", Nat. Chem. 2014, 6, 1072-1078.
6. Koeberle, E. Muñoz, G. B. Appendino, A. Minassi, S. Pace, A. Rossi, C. Weinigel, D. Barz, L. Sautebin, D. Caprioglio, J. A. Collado, O. Werz, "SAR studies on curcumin's pro-inflammatory targets: Discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase", J. Med. Chem. 2014, 57, 5638-5648.
7. Krämer, T. Mentrup, B. Kleizen, E. Rivera-Milla, D. Reichenbach, C. Enzensperger, R. Nohl, E. Täuscher, H. Görls, A. Ploubidou, C. Englert, O. Werz, H. D. Arndt, C. Kaether, "Small molecules for intercepting Notch signaling and the early secretory pathway", Nat. Chem. Biol. 2013, 9, 731-738.
8. Koeberle, H. Shindou, S. C. Koeberle, S. A. Laufer, T. Shimizu, O. Werz, "Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding", Proc. Natl. Acad. Sci. USA 2013, 110, 2546-2551.
9. Koeberle, J. Romir, S. Fischer, A. Koeberle, V. Schattel, W. Albrecht, C. Grütter, O. Werz, D. Rauh, T. Stehle, S. Laufer, "Skepinone-L: A p38 mitogen activated protein kinase (MAPK) inhibitor with unsurpassed selectivity and outstanding in vivo efficiency", Nat. Chem. Biol. 2012, 8, 141-143.
10. Pergola, G. Dodt, A. Rossi, E. Neunhoeffer, B. Lawrenz, H. Hinnak, B. Samuelsson, O. Rådmark, L. Sautebin, O. Werz, "ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma", Proc. Natl. Acad. Sci. USA 2008, 105, 19881-19886.