Institute for Molecular Cell Biology University Hospital Jena Hans-Knöll-Str. 2 07745 Jena Phone: + 49 3641 9 395 600 Fax: + 49 3641 9 395 602 carsten.Hoffmann@med.uni-jena.de Homepage
Functions
Head of the Institute for Molecular Cell Biology of the University Hospital Jena
Head of the Masterprogramme "Molecular Medicine"
Member of the Interdisciplinary Center for Clinical Research (IZKF) and the Jena School of Molecular Medicine (JSMM)
Research
Activation and regulation mechanisms of G protein-coupled receptors
Microscopy of signal transduction of GPCRs in real time
Development of FRET and BRET sensors for the visualisation of cellular processes in signal transduction
Publications (the 5 most important)
S. Nuber, U. Zabel, K. Lorenz, A. Nuber, G. Milligan, A. B. Tobin, M.J. Lohse, C. Hoffmann, “β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle”, Nature 2016, 531, 661-664.
S. C. Wright, M. C. Alonso Cañizal, T. Benkel, K. Simon, C. Le Gouill, P. Matricon, Y. Namkung, V. Lukasheva, G. M. König, S. A. Laporte, J. Carlsson, E. Kostenis, M. Bouvier, G. Schulte, C. Hoffmann, “FZD5 is a Gaq-coupled receptor exhibiting the functional hallmarks of prototypical GPCRs”, Sci. Signal. 2018, 11, 5536.
M. Grundmann, N. Merten, D. Malfacini, A. Inoue, P. Preis, K. Simon, N. Rüttiger, N. Ziegler, T. Benkel, N. K. Schmitt, S. Ishida, I. Müller, R. Reher, K. Kawakami, A. Inoue, U. Rick, T. Kühl, D. Imhof, J. Aoki, G. M. König, C. Hoffmann, J. Gomeza, J. Wess, E. Kostenis, “Lack of beta-arrestin signaling at “zero functional G””, Nat. Commun. 2018, 9, 341.
C. Perpiñá-Viciano, A. Işbilir, A. Zarca, B. Caspar, L. E. Kilpatrick, S. J. Hill, M. J. Smith, M. J. Lohse, C. Hoffmann, “Kinetic analysis of the early signaling steps of the human chemokine receptor CXCR4”, Mol. Pharm. 2020, 98, 72-87.
S. Erdogmus, U. Storch, L. Danner, J. Becker, M. Winter, N. Ziegler, A. Wirth, S. Offermanns, C. Hoffmann, T. Gudermann, M. Mederos y Schnitzler, “Helix 8 is the essential structural motif of mechanosensitive GPCRs”, Nat. Commun. 2019, 10, 5784.