Prof. Dr. Carsten Hoffmann

Functions

• Head of the Institute for Molecular Cell Biology of the University Hospital Jena
• Head of the Masterprogramme "Molecular Medicine"
• Member of the Interdisciplinary Center for Clinical Research (IZKF) and the Jena School of Molecular Medicine (JSMM) 
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Research

• Activation and regulation mechanisms of G protein-coupled receptors
• Microscopy of signal transduction of GPCRs in real time
• Development of FRET and BRET sensors for the visualisation of cellular processes in signal transduction

Publications (the 5 most important)

1. S. Nuber, U. Zabel, K. Lorenz, A. Nuber, G. Milligan, A. B. Tobin, M.J. Lohse, C. Hoffmann, “β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle”, Nature  2016, 531, 661-664.
2. S. C. Wright, M. C. Alonso Cañizal, T. Benkel, K. Simon, C. Le Gouill, P. Matricon, Y. Namkung, V. Lukasheva, G. M. König, S. A. Laporte, J. Carlsson, E. Kostenis, M. Bouvier, G. Schulte, C. Hoffmann, “FZD₅ is a Ga_q-coupled receptor exhibiting the functional hallmarks of prototypical GPCRs”, Sci. Signal.  2018, 11, 5536.
3. M. Grundmann, N. Merten, D. Malfacini, A. Inoue, P. Preis, K. Simon, N. Rüttiger, N. Ziegler, T. Benkel, N. K. Schmitt, S. Ishida, I. Müller, R. Reher, K. Kawakami, A. Inoue, U. Rick, T. Kühl, D. Imhof, J. Aoki, G. M. König, C. Hoffmann, J. Gomeza, J. Wess, E. Kostenis, “Lack of beta-arrestin signaling at “zero functional G””, Nat. Commun.  2018, 9, 341.
4. C. Perpiñá-Viciano, A. Işbilir, A. Zarca, B. Caspar, L. E. Kilpatrick, S. J. Hill, M. J. Smith, M. J. Lohse, C. Hoffmann, “Kinetic analysis of the early signaling steps of the human chemokine receptor CXCR4”, Mol. Pharm.  2020, 98, 72-87.
5. S. Erdogmus, U. Storch, L. Danner, J. Becker, M. Winter, N. Ziegler, A. Wirth, S. Offermanns, C. Hoffmann, T. Gudermann, M. Mederos y Schnitzler, “Helix 8 is the essential structural motif of mechanosensitive GPCRs”, Nat. Commun.  2019, 10, 5784.