apl. Prof. Dr. Michael Gottschaldt

Michael Gottschaldt Image: Michael Gottschaldt

Institute for Organic Chemistry and Macromolecular Chemistry
Friedrich Schiller University Jena
Humboldtstraße 10
07743 Jena
Phone: +49 3641 9 48 565
Fax:      +49 3641 9 48 202
michael.gottschaldt@uni-jena.de
Homepage

Functions

  • Research assistant at the Institute of Organic Chemistry and
    Macromolecular Chemistry (IOMC)
  • Scientific Director of the Jena Center for Soft Matter (JCSM)

Research

  • Stereoselective synthesis of mono- and disaccharide as well as nucleoside derivatives and coupling of metal-chelating units
  • Synthesis and structure elucidation of sugar metal complexes for use as chemotherapeutic agents, antibiotics and model substances for radioactive contrast agents
  • Preparation and analysis of glycopolymers with specific properties, e.g. LCST behavior, film-forming ability, cell adhesion, formation of micelles and nanoparticles

Publications (the10 most important)

  1. von der Ehe, T. Buś, C. Weber, S. Stumpf, P. Bellstedt, M. Hartlieb, U. S. Schubert, M. Gottschaldt, "Glycopolymer-Functionalized Cryogels as Catch and Release Devices for the Pre-Enrichment of Pathogens" ACS Macro Letters 2016, 5, 326-331.
  2. Prokop, J. A. Czaplewska, M. Dobroschke, M. König, A. Wild, R. Thorwirth, B. Schulze, K. Babiuch, D. Pretzel, U. S. Schubert, M. Gottschaldt, "Iridium(III) complexes of terpyridine and terpyridine analog ligands bearing sugar residues and their in vitro activity" Eur. J. Inorg. Chem. 2016, 3480-3488.
  3. Mueller, W. A. P. Breeman, I. Klette, M. Gottschaldt, A. Odparlik, M. Baehre, I. Tworowska, M. K. Schultz, "Radiolabeling of DOTA-like conjugated peptides with generator-produced 68Ga and using NaCl-based cationic elution method" Nat. Protocols 2016, 11, 1057-1066.
  4. v. d. Ehe, A. C. Rinkenauer, C. Weber, D. Szamosvari, M. Gottschaldt, U. S. Schubert, "Selective uptake of a fructose glycopolymer prepared by RAFT polymerization into human breast cancer cells" Macromol. Biosci. 2016, 16, 508-521.
  5. N. Leiske, M. Hartlieb, C. Paulenz, D. Pretzel, M. Hentschel, C. Englert, M. Gottschaldt, U. S. Schubert, "Lab in a tube: Purification, amplification, and detection of DNA using poly(2-oxazoline) multilayers" Adv. Funct. Mater. 2015, 25, 2458-2466.
  6. C. Zhao, K. Babiuch, H. X. Lu, A. Dag, M. Gottschaldt, M. H. Stenzel, "Fructose-coated nanoparticles: a promising drug nanocarrier for triple-negative breast cancer therapy" Chem. Commun. 2014, 50, 15928-15931.
  7. Tauhardt, D. Pretzel, K. Kempe, M. Gottschaldt, D. Pohlers, U. S. Schubert, "Zwitterionic poly(2-oxazoline)s as promising candidates for blood contacting applications" Polym. Chem. 2014, 5, 5751-5764.
  8. T. Press, A. Traeger, C. Pietsch, A. Mosig, M. Wagner, M. G. Clemens, N. Jbeily, N. Koch, M. Gottschaldt, N. Beziere, V. Ermolayev, V. Ntziachristos, J. Popp, M. M. Kessels, B. Qualmann, U. S. Schubert, M. Bauer, "Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles" Nat. Commun. 2014, 5.
  9. Englert, L. Tauhardt, M. Hartlieb, K. Kempe, M. Gottschaldt, U. S. Schubert, "Linear poly(ethylene imine)-based hydrogels for effective binding and release of DNA" Biomacromolecules 2014, 15, 1124-1131.
  10. Babiuch, D. Pretzel, T. Tolstik, A. Vollrath, S. Stanca, F. Foertsch, C. R. Becer, M. Gottschaldt, C. Biskup, U. S. Schubert, "Uptake of well-defined, highly glycosylated, pentafluorostyrene-based polymers and nanoparticles by human hepatocellular carcinoma cells" Macromol. Biosci. 2012, 12, 1190-1199.
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