Section for Experimental Virology Institute for Medical Microbiology University Hospital Jena Hans-Knöll-Str. 2 07745 Jena Telefon: + 49 3641 9 395 701 Telefax: + 49 3641 9 395 702 Christina.Ehrhardt@med.uni-jena.de
Functions
Head of the Section for Experimental Virology (W2 professorship)
Graduate School of Excellence (JSMC)
Research
Pathogen-induced cellular signalling mechanisms with focus on viral respiratory pathogens (influenza viruses, respiratory syncytial viruses, rhinoviruses)
Investigation of the pathogen-host interaction of viral and bacterial respiratory pathogens (e.g.Staphylococcus aureus) or fungi (e.g. Aspergillus fumigatus) in simple and complex infection models
Investigation of cellular factors as targets for anti-pathogenic strategies
Publications (the 5 most important)
A. van Krüchten, J. J. Wilden, S. Niemann, G. Peters, B. Löffler, S. Ludwig, C. Ehrhardt, "Staphylococcus aureus triggers a shift from influenza virus-induced apoptosis to necrotic cell death", FASEB J.2018, 32, 5: 2779-93.
Bruchhagen, M. Jarick, C. Mewis, T. Hertlein, S. Niemann, K. Ohlsen, G. Peters, O. Planz, S. Ludwig, C. Ehrhardt, "Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound", Sci. Rep.2018, 1, 9114.
C. Klemm, Y. Boergeling, S. Ludwig, C. Ehrhardt, "Immunomodulatory nonstructural proteins of influenza A viruses", Trends Microbiol. 2018, 26, 624-636.
H. F. Preugschas, E. R. Hrincius, C. Mewis, G. V. Q. Tran, S. Ludwig, C. Ehrhardt, "Late activation of the Raf/MEK/ERK pathway is required for translocation of the Respiratory Syncytial Virus F protein to the plasma membrane and efficient viral replication", Cell. Microbiol. 2019,21, e12955.
M. Holzberg, Y. Boergeling, T. Schrader, S. Ludwig, C. Ehrhardt, "Vemurafenib limits influenza A virus propagation by targeting multiple signaling pathways", Front. Microbiol. 2017,8, 2426.