Prof. Dr. Christina Ehrhardt

Functions

• Head of the Section for Experimental Virology (W2 professorship)
• Graduate School of Excellence (JSMC)

Research

• Pathogen-induced cellular signalling mechanisms with focus on viral respiratory pathogens (influenza viruses, respiratory syncytial viruses, rhinoviruses)
• Investigation of the pathogen-host interaction of viral and bacterial respiratory pathogens (e.g. Staphylococcus aureus) or fungi (e.g. Aspergillus fumigatus) in simple and complex infection models
• Investigation of cellular factors as targets for anti-pathogenic strategies

Publications (the 5 most important)

1. A. van Krüchten, J. J. Wilden, S. Niemann, G. Peters, B. Löffler, S. Ludwig, C. Ehrhardt, "Staphylococcus aureus triggers a shift from influenza virus-induced apoptosis to necrotic cell death", FASEB J. 2018, 32, 5: 2779-93.
2. Bruchhagen, M. Jarick, C. Mewis, T. Hertlein, S. Niemann, K. Ohlsen, G. Peters, O. Planz, S. Ludwig, C. Ehrhardt, "Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound", Sci. Rep. 2018, 1, 9114.
3. C. Klemm, Y. Boergeling, S. Ludwig, C. Ehrhardt, "Immunomodulatory nonstructural proteins of influenza A viruses", Trends Microbiol. 2018, 26, 624-636.
4. H. F. Preugschas, E. R. Hrincius, C. Mewis, G. V. Q. Tran, S. Ludwig, C. Ehrhardt, "Late activation of the Raf/MEK/ERK pathway is required for translocation of the Respiratory Syncytial Virus F protein to the plasma membrane and efficient viral replication", Cell. Microbiol. 2019, 21, e12955.
5. M. Holzberg, Y. Boergeling, T. Schrader, S. Ludwig, C. Ehrhardt, "Vemurafenib limits influenza A virus propagation by targeting multiple signaling pathways", Front. Microbiol. 2017, 8, 2426.