Prof. Dr. Michael Börsch

Functions

• Head of the interdisciplinary research group Microscopy Methodology

Research

• Single molecule-based fluorescence spectroscopic studies of the conformational dynamics of FoF1-ATP synthases from E. coli,
• Conformational dynamics of individual G protein-coupled receptors and transport ATPases (neuroteins recpetor 1, Pgp, KdpFABC, V-ATPase, A-ATP synthase) in vitro and in vivo, 
• Polymer-based and exosomal native lipid nanoparticles for early cancer cell diagnostics
• Ps-time-resolved single molecule FRET microscopy, FLIM, anisotropy microscopy, superlocalization- and STED superresolution microscopies, fluorescence correlation spectroscopy, 
• Confocal ABEL trap (anti-Brownian electrokinetic trap)
• NV-center-based quantum sensing of protein dynamics usings nanodiamonds
• Publications (selected 5 most recent)

Publications (selected 5 most recent)

1. I. Pérez, T. Heitkamp, M. Börsch, Mechanism of ADP-Inhibited ATP Hydrolysis in Single Proton-Pumping FoF1-ATP Synthase Trapped in Solution 2023 Int. J. Mol. Sci. 24, 8442. 
2. T. Heitkamp, M. Börsch, Fast ATP-Dependent Subunit Rotation in Reconstituted FoF1‑ATP Synthase Trapped in Solution 2021 J. Phys. Chem. B 125, 7638-7650.
3. H. Sielaff, S. Yanagisawa, W. D. Frasch, W. Junge, M. Börsch, Structural asymmetry and kinetik limping of single rotary F-ATP synthases 2019 Molecules 24, 504.
4. J.-P. Günther, M. Börsch, P. Fischer, Diffusion Measurements of Swimming Enzymes with Fluorescence Correlation Spectroscopy 2018 Acc. Chem. Res. 51, 1911-1920.
5. M. Weiss, J. P. Frohnmayer, L. T. Benk, B. Haller, J.-W. Janiesch, T. Heitkamp, M. Börsch, R. B. Lira, R. Dimova, R. Lipowsky, E. Bodenschatz, J.-C. Baret, T. Vidakovic-Koch, K. Sundmacher, I. Platzman, J. Spatz, Sequential bottom-up assembly of mechanically stabilized synthetic cells by microfluidics 2018 Nature Materials 17, 89-96.