Prof. Dr. Michael Börsch
Research Group Mikroskopie-Methodik
University Hosptial Jena
Nonnenplan 4
07743 Jena
Phone: +49 3641 9 396 618
Fax : +49 3641 9 337 50
michael.boersch@med.uni-jena.de
Hompage
Functions
- Head of the interdisciplinary research group Microscopy Methodology
Research
- Single molecule-based fluorescence spectroscopic studies of the conformational dynamics of FoF1 ATP synthases from E. coli (biological nanomotor), ps time-resolved single-molecule FRET microscopy
- FLIM, ABELtrap, superresolution microscopy, black-lipid-membranes, hidden Markov models
- Conformational dynamics of individual membrane-bound transport ATPases (Pgp, KdpFABC, V-ATPase, A-ATP synthase), anisotropy microscopy, fluorescence correlation spectroscopy
- Ultrasensitive evidence for biochemical polymer degradation (nanocellulose)
- Local redox chemistry on nanoelectrodes (pH gradient for driving the ATP synthases), patch-clamp methods
- Fluorescence spectroscopic investigations of individual polymers (DNA block copolymers, poly-Bodipy dyes) and ultrastable perylenes
Publications (the 5 most important)
- M. G. Düser, N. Zarrabi, D. J. Cipriano, S. Ernst, G. D. Glick, S.D. Dunn, M. Börsch, 36° step size of proton-driven c-ring rotation in FoF1-ATP synthase 2009 EMBO Journal 28, 2689-2696. (rated by Faculty-of-1000)
- N. Zarrabi, S. Ernst, B. Verhalen, S. Wilkens, M. Börsch, Analyzing conformational dynamics of single P-glycoprotein transporters by Förster resonance energy transfer using hidden Markov models 2014 Methods 66, 168-179
- H. Sielaff, M. Börsch, Twisting and subunit rotation in single FOF1-ATP synthase 2013 Phil. Trans. Royal Soc. B 368, 20120024
- S. Ernst, M. G. Düser. N. Zarrabi, M. Börsch, Three-color Förster resonance energy transfer within single FOF1-ATP synthases: monitoring elastic deformations of the rotary double motor in real time 2012 J. Biomed. Opt. 17, 011004. (with cover page)
- F. E. Alemdaroglu, S. C. Alexander, D. Ji, D. K. Prusty, M. Börsch, A. Herrmann, Poly(BODIPY)s: a new class of tunable polymeric dyes 2009 Macromolecules 42, 6529-6536.